KANEKA KanCapA™ is a alkaline stable protein A affinity resin suitable for industrial scale purification of monoclonal antibodies. The Protein A ligand is a C-domain based pentamer that exhibits high alkaline stability and negligible Fab binding.
> Alkaline stability and long lifetime
> High flow rate operation and easy to scale up from pilot to process
> Track record of successful mAb GMP manufacturing for clinical trial materials
KANEKA KanCapA™ ‘s ligand exhibits superior resistance to sodium hydroxide cleaning. The resin can be safely used up to 300 cycles with 0.1 M sodium hydroxide as the CIP solution with 15 minutes of contact time maintaining its binding capacity.
KANEKA KanCapA™ ‘s ligand binding ability to Fab region was eliminated in order to use mild acidic conditions for monoclonal antibody elution.
KANEKA KanCapA™ has been designed for efficient antibody capture achieving a high binding capacity at 4 to 6 minutes residence time.
Due to its matrix KANEKA KanCapA™ resin is perfectly suited for pilot and large scale purification processes. It can be efficiently packed into columns of various sizes either by normal flow or by axial compression methods. Packed columns show excellent pressure/flow rate characteristics and excellent performance.
KANEKA KanCapA™ is available in various formats adapted to all stages of the purification process from method optimization and process development to commercial manufacturing.
|Product Name||Format||Volume||Catalog Number|
|KANEKA KanCapA™||Prepacked Column||1mL||KPA02-C001|
|RoboColumn®||200µL x 8 row||KPA02-S200|
|600µL x 8 row||KPA02-S600|
|Bulk Resin||25 mL||KPA02-B025|
1. Pressure flow characteristics & scalability of Kaneka KanCapA™ and
KanCapA™ 3G (Download the technical note)
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